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KMID : 0604520100360040295
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Journal of the Society of Cosmetic Scientists of Korea
2010 Volume.36 No. 4 p.295 ~ p.301
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Anti-Aging Effect of Ligustrum japonicum Extract in the Human Fibroblast Cells
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Kim Yun-Jeong
Lee Yu-Ri
Cheon Jong-Woo
Lee Hyun-Sang
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Abstract
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To develop wrinkle care cosmetic ingredients, various species of plant extracts were investigated. Accordingly, Ligustrum japonicum was selected as a candidate for developing cosmetic ingredient. By high performance liquid chromatography, 31.06 % of oleanolic acid and 8.92 % of ursolic acid which are well-known for anti-wrinkle effect were analyzed. The possibility of Ligustrum japonicum fruits extract (LJE) as a cosmetic ingredient was investigated using several biomarkers related to anti-aging, including anti-wrinkle, moisturizing and anti-inflammation. Procollagen type I and hyaluronan synthase-3 gene expression were increased by LJE in a concentration-dependent manner, whereas elastase activity and matrix metalloproteinase (MMP)-1, MMP-2 and cyclooxygenase-2 gene expression were inhibited. As the results LJE is applicable for a potential cosmetic ingredient focused on anti-aging effect.
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KEYWORD
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Ligustrum japonicum, procollagen type I, hyaluronan synthase-3, matrix metalloproteinases, cyclooxygenase-2
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